{"id":4284,"date":"2023-09-27T12:14:14","date_gmt":"2023-09-27T17:14:14","guid":{"rendered":"https:\/\/cqfa.quebec\/?p=4284"},"modified":"2023-09-27T13:24:32","modified_gmt":"2023-09-27T18:24:32","slug":"a-handheld-bioprinter-for-multi-material-printing-of-complex-constructs","status":"publish","type":"post","link":"https:\/\/cqfa.quebec\/en\/a-handheld-bioprinter-for-multi-material-printing-of-complex-constructs\/","title":{"rendered":"A handheld bioprinter for multi-material printing of complex constructs"},"content":{"rendered":"

Pagan, E.; <\/span>Stefanek<\/span>, E.; <\/span>Seyfoori<\/span>, A.; <\/span>Razzaghi<\/span>, M.; <\/span>Chehri<\/span>, B.; <\/span>Mousavi<\/span>, A.; <\/span>Arnaldi<\/span>, P.; <\/span>Ajji<\/span>, Z.; <\/span>Ravizonni<\/span> Dartora<\/span>, D.; Hossein <\/span>Dabiri<\/span>, S.M.;<\/span> Nuyt<\/span>, A.M.; <\/span>Khademhosseini<\/span>, A.; <\/span>Savoji<\/span>, H.; <\/span>Akbari<\/span>, M. (2023). <\/span><\/span>A handheld bioprinter for multi-material printing of complex constructs.<\/span> <\/span>Biofabrication<\/span>, <\/span>vol. <\/span>15<\/span> (2023) 035012.<\/span><\/span><\/em><\/p>\n

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In situ bioprinting\u2014the process of depositing bioinks at a defected area, has recently <\/span>emerged<\/span> as a versatile technology for tissue repair and restoration via site-specific delivery of pro-healing constructs. The ability to print multiple materials in situ is an exciting approach that allows simultaneous or sequential dispensing of <\/span>different materials<\/span> and cells to achieve tissue biomimicry. Herein, we report a modular handheld bioprinter that deposits a variety of bioinks in situ with exquisite control over their physical and chemical properties. Combined stereolithography 3D printing and microfluidic technologies allowed us to develop a novel low-priced handheld bioprinter. The ergonomic design of the handheld bioprinter facilitate the shape-controlled <\/span>biofabrication<\/span> of multi-<\/span>component<\/span> fibers with different cross-sectional shapes and material compositions. Furthermore, the capabilities of the produced fibers in the local delivery of therapeutic agents <\/span>was<\/span> demonstrated<\/span> by incorporating drug-loaded microcarriers, extending the application of the printed fibers to on-demand, temporal, and dosage-control drug delivery platforms. Also, the versatility of this platform to produce biosensors and wearable electronics was <\/span>demonstrated<\/span> via incorporating conductive materials and integrating pH-responsive dyes. The handheld printer’s efficacy in generating cell-laden fibers with high cell viability for site-specific cell delivery was shown by producing single-component and multi-<\/span>component<\/span> cell-laden fibers. In particular, the multi-<\/span>component<\/span> fibers were able to model the invasion of cancer cells into the adjacent tissue.<\/span><\/span>\u00a0<\/span><\/p>\n

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Read the publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Pagan, E.; Stefanek, E.; Seyfoori, A.; Razzaghi, M.; Chehri, B.; Mousavi, A.; Arnaldi, P.; Ajji, Z.; Ravizonni Dartora, D.; Hossein Dabiri, S.M.; Nuyt, A.M.; Khademhosseini, A.; Savoji, H.; Akbari, M. […]<\/p>\n","protected":false},"author":80,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[43],"tags":[],"class_list":["post-4284","post","type-post","status-publish","format-standard","hentry","category-publications-academiques-quebecoises"],"acf":[],"yoast_head":"\nA handheld bioprinter for multi-material printing of complex constructs - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cqfa.quebec\/en\/a-handheld-bioprinter-for-multi-material-printing-of-complex-constructs\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A handheld bioprinter for multi-material printing of complex constructs - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive\" \/>\n<meta property=\"og:description\" content=\"Pagan, E.; Stefanek, E.; Seyfoori, A.; Razzaghi, M.; Chehri, B.; Mousavi, A.; Arnaldi, P.; Ajji, Z.; Ravizonni Dartora, D.; Hossein Dabiri, S.M.; Nuyt, A.M.; Khademhosseini, A.; Savoji, H.; Akbari, M. 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