{"id":4293,"date":"2023-09-28T07:32:07","date_gmt":"2023-09-28T12:32:07","guid":{"rendered":"https:\/\/cqfa.quebec\/?p=4293"},"modified":"2023-09-28T07:39:19","modified_gmt":"2023-09-28T12:39:19","slug":"developpement-de-patchs-perfusables-par-bioimpression-3d-pour-une-application-potentielle-dans-la-regeneration-de-tissu-cardiaque","status":"publish","type":"post","link":"https:\/\/cqfa.quebec\/en\/developpement-de-patchs-perfusables-par-bioimpression-3d-pour-une-application-potentielle-dans-la-regeneration-de-tissu-cardiaque\/","title":{"rendered":"D\u00e9veloppement de patchs perfusables par bioimpression 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque"},"content":{"rendered":"<p><em><span class=\"TextRun SCXW68971459 BCX0\" lang=\"FR-CA\" xml:lang=\"FR-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW68971459 BCX0\">Ajjiz<\/span><span class=\"NormalTextRun SCXW68971459 BCX0\">, Z. (2023). <\/span><\/span><span class=\"TextRun SCXW68971459 BCX0\" lang=\"FR-CA\" xml:lang=\"FR-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW68971459 BCX0\" data-ccp-charstyle=\"normaltextrun\" data-ccp-charstyle-defn=\"{&quot;ObjectId&quot;:&quot;a708ac02-62c9-492f-9ace-33c3dca10204|50&quot;,&quot;ClassId&quot;:1073872969,&quot;Properties&quot;:[469775450,&quot;normaltextrun&quot;,201340122,&quot;1&quot;,134233614,&quot;true&quot;,469778129,&quot;normaltextrun&quot;,335572020,&quot;1&quot;,469778324,&quot;Default Paragraph Font&quot;]}\">D\u00e9veloppement de patchs <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW68971459 BCX0\" data-ccp-charstyle=\"normaltextrun\">perfusables<\/span><span class=\"NormalTextRun SCXW68971459 BCX0\" data-ccp-charstyle=\"normaltextrun\"> par <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW68971459 BCX0\" data-ccp-charstyle=\"normaltextrun\">bioimpression<\/span><span class=\"NormalTextRun SCXW68971459 BCX0\" data-ccp-charstyle=\"normaltextrun\"> 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque. Thesis.<\/span><\/span><\/em><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"NormalTextRun SCXW177847282 BCX0\">Cardiovascular diseases are a leading cause of death worldwide. Myocardial infarction captures a significant segment of this population, and the end-stage myocardial infarction can only be treated by heart transplantation. However, due to the scarcity donors, tissue engineering has been considered as an alternative solution. Tissue engineering allows the development of tissues and therapeutic implants such as cardiac patches. However, one of the main hurdles in the use of such a strategy is the vascularization of <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">bioprinted<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> tissue. In this study, 3D bioprinting was used to <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">bioprint<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">perfusable<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> gelatin methacrylate (<\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">GelMA<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\">) patches for a potential use in cardiac tissue. This work consists in the development of a bioink that can be used for the cardiac tissue, the evaluation of the printability of the ink, and the final bioprinting of standard and <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">perfusable<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> patches. For this purpose, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">GelMA<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> was synthesized and a final concentration of 10 % was selected as it showed <\/span><span class=\"NormalTextRun SCXW177847282 BCX0\">an appropriate Young&#8217;s<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> modulus for cardiac tissue, of 23.7\u00b15.1 kPa, while <\/span><span class=\"NormalTextRun SCXW177847282 BCX0\">maintaining<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> high biocompatibility. Subsequently, the printing process of standard and <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">perfusable<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> patches could be <\/span><span class=\"NormalTextRun SCXW177847282 BCX0\">optimized<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> with the use of <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">GelMA<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> and gelatin inks. Finally, 10% <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">GelMA<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> and 2% gelatin vascularized patches could be printed with high cell viability, of up to 79,7\u00b18,7 % and 83,5\u00b15,7 % on days 1 and 7 of culture respectively for 3T3 fibroblasts. Additionally, the presence of hollow channels of the <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW177847282 BCX0\">perfusable<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> patches <\/span><span class=\"NormalTextRun SCXW177847282 BCX0\">demonstrates<\/span><span class=\"NormalTextRun SCXW177847282 BCX0\"> the potential of this method to be eventually applied to the bioprinting of thick vascularized cardiac patches.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"link-btn-style btn-yellow\"><a href=\"https:\/\/papyrus.bib.umontreal.ca\/xmlui\/bitstream\/handle\/1866\/28410\/Ajji_Zineb_2022_memoire.pdf?sequence=2\" target=\"_blank\" rel=\"noopener\">Read the publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ajjiz, Z. (2023). D\u00e9veloppement de patchs perfusables par bioimpression 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque. Thesis. &nbsp; Cardiovascular diseases are a leading cause of death [&hellip;]<\/p>\n","protected":false},"author":80,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[43],"tags":[],"class_list":["post-4293","post","type-post","status-publish","format-standard","hentry","category-publications-academiques-quebecoises"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>D\u00e9veloppement de patchs perfusables par bioimpression 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cqfa.quebec\/en\/developpement-de-patchs-perfusables-par-bioimpression-3d-pour-une-application-potentielle-dans-la-regeneration-de-tissu-cardiaque\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"D\u00e9veloppement de patchs perfusables par bioimpression 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive\" \/>\n<meta property=\"og:description\" content=\"Ajjiz, Z. (2023). D\u00e9veloppement de patchs perfusables par bioimpression 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque. Thesis. &nbsp; Cardiovascular diseases are a leading cause of death [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/cqfa.quebec\/en\/developpement-de-patchs-perfusables-par-bioimpression-3d-pour-une-application-potentielle-dans-la-regeneration-de-tissu-cardiaque\/\" \/>\n<meta property=\"og:site_name\" content=\"CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive\" \/>\n<meta property=\"article:published_time\" content=\"2023-09-28T12:32:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-28T12:39:19+00:00\" \/>\n<meta name=\"author\" content=\"f.charreteur\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"f.charreteur\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/cqfa.quebec\/en\/developpement-de-patchs-perfusables-par-bioimpression-3d-pour-une-application-potentielle-dans-la-regeneration-de-tissu-cardiaque\/\",\"url\":\"https:\/\/cqfa.quebec\/en\/developpement-de-patchs-perfusables-par-bioimpression-3d-pour-une-application-potentielle-dans-la-regeneration-de-tissu-cardiaque\/\",\"name\":\"D\u00e9veloppement de patchs perfusables par bioimpression 3D pour une application potentielle dans la r\u00e9g\u00e9n\u00e9ration de tissu cardiaque - 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