{"id":4300,"date":"2023-09-28T08:02:23","date_gmt":"2023-09-28T13:02:23","guid":{"rendered":"https:\/\/cqfa.quebec\/?p=4300"},"modified":"2023-09-28T08:38:41","modified_gmt":"2023-09-28T13:38:41","slug":"tumor-shape-specific-brachytherapy-implants-by-3d-printing-precision-radioactivity-painting-and-biomedical-imaging","status":"publish","type":"post","link":"https:\/\/cqfa.quebec\/en\/tumor-shape-specific-brachytherapy-implants-by-3d-printing-precision-radioactivity-painting-and-biomedical-imaging\/","title":{"rendered":"Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging"},"content":{"rendered":"<p><em><span class=\"TextRun SCXW123575784 BCX0\" lang=\"FR-CA\" xml:lang=\"FR-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123575784 BCX0\">Lescot, T.; Lebel-Cormier M.A.; <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW123575784 BCX0\">Seniwal<\/span><span class=\"NormalTextRun SCXW123575784 BCX0\">, B.; Gros-Louis, P.; Bellerive, C.; Landreville, S.; Beaulieu, L.; Fortin, M.A. (2023). <\/span><\/span><span class=\"TextRun Highlight SCXW123575784 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123575784 BCX0\" data-ccp-charstyle=\"normaltextrun\" data-ccp-charstyle-defn=\"{&quot;ObjectId&quot;:&quot;a708ac02-62c9-492f-9ace-33c3dca10204|50&quot;,&quot;ClassId&quot;:1073872969,&quot;Properties&quot;:[469775450,&quot;normaltextrun&quot;,201340122,&quot;1&quot;,134233614,&quot;true&quot;,469778129,&quot;normaltextrun&quot;,335572020,&quot;1&quot;,469778324,&quot;Default Paragraph Font&quot;]}\">Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging<\/span><\/span><span class=\"TextRun Highlight SCXW123575784 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123575784 BCX0\" data-ccp-charstyle=\"normaltextrun\">. <\/span><\/span><span class=\"TextRun Highlight SCXW123575784 BCX0\" lang=\"FR-CA\" xml:lang=\"FR-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW123575784 BCX0\" data-ccp-charstyle=\"normaltextrun\">Adv. Healthcare Mater. 2023, 2300528<\/span><span class=\"NormalTextRun SCXW123575784 BCX0\" data-ccp-charstyle=\"normaltextrun\">.<\/span><\/span><\/em><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"TextRun Highlight SCXW97510784 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SCXW97510784 BCX0\">In brachytherapy (BT), or internal radiation therapy, cancer is treated by radioactive implants. For instance, episcleral plaques (EPs) for the treatment of uveal melanoma, are designed according to generic population approximations. However, more personalized implants can enhance treatment precision through better adjustment of dose profiles to the contours of cancerous tissues. An original approach integrating biomedical imaging, 3D printing, radioactivity painting, and biomedical imaging, is developed as a workflow for the development of tumor shape-specific BT implants. First, computer-aided design plans of EP are prepared according to guidelines prescribed by the Collaborative Ocular Melanoma Study protocol. <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW97510784 BCX0\">Polyetheretherketone<\/span><span class=\"NormalTextRun SCXW97510784 BCX0\"> (PEEK), a high-performance polymer suitable for permanent implants, is used to 3D-print plaques and the geometrical accuracy of the printed design is evaluated by imaging. The possibility to modulate the dose distribution in a tridimensional manner is <\/span><span class=\"NormalTextRun SCXW97510784 BCX0\">demonstrated<\/span><span class=\"NormalTextRun SCXW97510784 BCX0\"> by painting the inner surfaces of the EPs with radioactive 103Pd, followed by dose profile measurements. The possibility to modulate dose distributions generated by these 3D-printed plaques through radioactivity painting is therefore confirmed. Ex vivo surgical tests on human eyeballs are performed as an assessment of manipulation ease. Overall, this work <\/span><span class=\"NormalTextRun SCXW97510784 BCX0\">provides<\/span><span class=\"NormalTextRun SCXW97510784 BCX0\"> a solution for the fabrication of tumor-specific radioactive implants requiring higher dose precision.<\/span><\/span><span class=\"EOP SCXW97510784 BCX0\" data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:160,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"link-btn-style btn-yellow\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/adhm.202300528\" target=\"_blank\" rel=\"noopener\">Read the publication<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lescot, T.; Lebel-Cormier M.A.; Seniwal, B.; Gros-Louis, P.; Bellerive, C.; Landreville, S.; Beaulieu, L.; Fortin, M.A. (2023). Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging. Adv. [&hellip;]<\/p>\n","protected":false},"author":80,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[43],"tags":[],"class_list":["post-4300","post","type-post","status-publish","format-standard","hentry","category-publications-academiques-quebecoises"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cqfa.quebec\/en\/tumor-shape-specific-brachytherapy-implants-by-3d-printing-precision-radioactivity-painting-and-biomedical-imaging\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive\" \/>\n<meta property=\"og:description\" content=\"Lescot, T.; Lebel-Cormier M.A.; Seniwal, B.; Gros-Louis, P.; Bellerive, C.; Landreville, S.; Beaulieu, L.; Fortin, M.A. (2023). Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging. Adv. 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Tumor Shape-Specific Brachytherapy Implants by 3D-Printing, Precision Radioactivity Painting, and Biomedical Imaging. Adv. 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