{"id":4524,"date":"2023-11-15T11:00:56","date_gmt":"2023-11-15T16:00:56","guid":{"rendered":"https:\/\/cqfa.quebec\/?p=4524"},"modified":"2023-11-15T11:04:09","modified_gmt":"2023-11-15T16:04:09","slug":"improving-the-3d-printability-of-sugar-glass-to-engineer-sacrificial-vascular-templates","status":"publish","type":"post","link":"https:\/\/cqfa.quebec\/en\/improving-the-3d-printability-of-sugar-glass-to-engineer-sacrificial-vascular-templates\/","title":{"rendered":"Improving the 3D Printability of Sugar Glass to Engineer Sacrificial Vascular Templates"},"content":{"rendered":"<p><em><span class=\"TextRun SCXW204748672 BCX0\" lang=\"FR-CA\" xml:lang=\"FR-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Moeun<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">, B.N.; Fernandez, S.A.; <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Collin<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">, S.; Gauvin-Rossignol<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">, G.; Lescot, T.; Fortin, M.A; Ruel, J.; B\u00e9gin-Drolet, A.; <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Leask<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">, R.L.; <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Hoesli<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">, C.A. (2023). <\/span><\/span><span class=\"TextRun SCXW204748672 BCX0\" lang=\"FR-CA\" xml:lang=\"FR-CA\" data-contrast=\"none\"><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Improving<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\"> the 3D <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Printability<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\"> of Sugar Glass to <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Engineer<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Sacrificial<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Vascular<\/span> <span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Templates<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">.<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\"> 3D Printing and Additive <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">Manufacturing<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\">, Volume 10, Issue 5, <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW204748672 BCX0\">October<\/span><span class=\"NormalTextRun SCXW204748672 BCX0\"> 2023, Pages 855-1163.<\/span><\/span><\/em><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">A prominent obstacle in scaling up tissue engineering technologies for human applications is engineering an adequate supply of oxygen and nutrients throughout artificial tissues. Sugar glass has <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">emerged<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> as a promising 3D-printable, sacrificial material that can be used to embed <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW86352387 BCX0\">perfusable<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> networks within cell-laden matrices to improve mass transfer. To characterize and <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">optimize<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> a previously published sugar ink, we investigated the effects of sucrose, glucose, and dextran concentration on the glass transition temperature (<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">T<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun Subscript SCXW86352387 BCX0\" data-fontsize=\"11\">g<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">), printability, and stability of 3D-printed sugar glass constructs. We <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">identified<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> a sucrose ink formulation with a significantly higher\u00a0<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">T<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun Subscript SCXW86352387 BCX0\" data-fontsize=\"11\">g<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">\u00a0(40.0\u2009\u00b1\u20090.9\u00b0C) than the original formulation (sucrose-glucose blend,\u00a0<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">T<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun Subscript SCXW86352387 BCX0\" data-fontsize=\"11\">g<\/span><\/span><span class=\"TextRun SCXW86352387 BCX0\" lang=\"EN-CA\" xml:lang=\"EN-CA\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW86352387 BCX0\">\u2009=\u200926.2\u2009\u00b1\u20090.4\u00b0C), which <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">demonstrated<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> a pronounced improvement in printability, resistance to bending, and final print stability, all without changing dissolution kinetics and decomposition temperature. This formulation allowed printing of 10-cm-long horizontal cantilever filaments, which can enable the printing of complex vascular segments along the x-, y-, and z-axes without the need for supporting structures. Vascular templates with a single inlet and outlet branching into nine channels were 3D printed using the improved formulation and <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">subsequently<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> used to generate <\/span><span class=\"NormalTextRun SpellingErrorV2Themed SCXW86352387 BCX0\">perfusable<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> alginate constructs. The printed lattice showed high fidelity with respect to the input geometry, although with some channel deformation after alginate casting and gelation\u2014<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">likely due<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> to alginate swelling. Compared with avascular controls, no significant acute cytotoxicity was noted when casting pancreatic beta cell-laden alginate constructs around improved ink filaments, <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">whereas<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> a significant decrease in cell viability was <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">observed<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> with the original ink. The improved formulation lends more flexibility to sugar glass 3D printing by <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">facilitating<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> the fabrication of larger, more complex, and more stable sacrificial networks. Rigorous characterization and optimization methods for improving sacrificial inks may <\/span><span class=\"NormalTextRun SCXW86352387 BCX0\">facilitate<\/span><span class=\"NormalTextRun SCXW86352387 BCX0\"> the fabrication of functional cellular constructs for tissue engineering, cellular biology, and other biomedical applications.<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p class=\"link-btn-style btn-yellow\"><a href=\"https:\/\/www.liebertpub.com\/doi\/10.1089\/3dp.2021.0147\" target=\"_blank\" rel=\"noopener\">Read the publication<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Moeun, B.N.; Fernandez, S.A.; Collin, S.; Gauvin-Rossignol, G.; Lescot, T.; Fortin, M.A; Ruel, J.; B\u00e9gin-Drolet, A.; Leask, R.L.; Hoesli, C.A. (2023). Improving the 3D Printability of Sugar Glass to Engineer [&hellip;]<\/p>\n","protected":false},"author":80,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"footnotes":""},"categories":[43],"tags":[],"class_list":["post-4524","post","type-post","status-publish","format-standard","hentry","category-publications-academiques-quebecoises"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Improving the 3D Printability of Sugar Glass to Engineer Sacrificial Vascular Templates - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/cqfa.quebec\/en\/improving-the-3d-printability-of-sugar-glass-to-engineer-sacrificial-vascular-templates\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Improving the 3D Printability of Sugar Glass to Engineer Sacrificial Vascular Templates - CQFA - Carrefour qu\u00e9b\u00e9cois de la fabrication additive\" \/>\n<meta property=\"og:description\" content=\"Moeun, B.N.; Fernandez, S.A.; Collin, S.; Gauvin-Rossignol, G.; Lescot, T.; Fortin, M.A; Ruel, J.; B\u00e9gin-Drolet, A.; Leask, R.L.; Hoesli, C.A. 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